Antibacterial activity of hyperforin from St. John's wort
Extracts from Saint John's wort (Hypericum perforatum) are traditionally used as a mild psychotropic agent or to aid wound healing. The antibiotic compound produced by the plant was termed hyperforin. The recent availability of hyperforin in quantity and sufficient purity allowed investigations to the range of antibacterial activity. It was found to be inhibitory to Staphylococcus aureus multiresistant to conventional antibiotics as well as against other Gram-positive bacteria.
Preliminary tests indicate that hyperforin may be suitable to be orally administered in addition to local treatment of skin lesions.
The structure of hyperforin is derived from phloroglucinol which is expanded into a bicyclo [3,3,1] nonaendionol, substituted with several lipophilic isoprene chains. No other known antibiotic is similar in structure to hyperforin.
